From Polotsk to Tver
Simeon was descended from the princes of Polotsk and served as the seventh bishop of that ancient Rus' see. According to the synaxarion, his episcopal seat was initially located at Polotsk but was relocated amid hostilities and conflicts involving Lithuanian princes and the murder of a local prince.
This upheaval reflects the wider pressures on Polotsk in the thirteenth century: pagan Lithuanians had begun consolidating the lands of the principality, and in 1240 Polotsk became a vassal of the Grand Duchy of Lithuania. Against this background Simeon's see was transferred eastward to Tver.