Defense of the Nicene Faith
Eusebius stood firmly for the Orthodox Confession of Faith proclaimed at the First Ecumenical Council of Nicaea in 325, and he suffered persecution by the Arians throughout his episcopate, being repeatedly deprived of his see and banished.
He had been entrusted with the official record of the 360 election of Meletius of Antioch. When Meletius proved to be Orthodox rather than sympathetic to the Arian cause that had expected to favor him, Arian bishops persuaded the Arian-supporting Emperor Constantius II to compel Eusebius to surrender the document. According to the synaxarion, when threatened with the loss of his hands he stretched out both, replying that they might be cut off but that he would not give up the conciliar decree; the emperor marveled but did not harm him.