Historical Context
The martyrdom is set during the reign of Shapur II of Persia, whose campaigns against Roman Mesopotamia beginning around 337 opened an extended period of conflict. Within his realm Christians were subjected to persecution, understood in part as a reaction against the Emperor Constantine the Great's open promotion of Christianity in the Roman world.
According to one tradition, Shapur besieged and captured the fortified town of Bet Zabdai, taking Heliodorus and other captives into Persia. The synaxarion tradition further describes the king as actively demolishing churches, breaking sacred icons, and burning the relics of the saints.