Historical Context
The episode is set during the persecution under the emperor Diocletian, conventionally dated to about 302, which places Domnina and her daughters in the early fourth century. According to the tradition, the family fled Antioch and sought refuge in Edessa to escape the pressure of their pagan kin.
Berenice's father and her husband, who were pagans, took the women from their refuge toward Hieropolis in Syria. The soldiers escorting them stopped to rest and to drink wine, and the women used the interval to escape their guards. To avoid capture and violation, they went down to a river that flowed nearby and drowned themselves in its current.